Use of Chinese Medicine and Subsequent Surgery in Women with Uterine Fibroid:
A Retrospective Cohort Study
Shan-Yu Su, Chih-Hsin Muo, and Donald E. Morisky
Background: Chinese medicine (CM) has been used to relieve symptoms relevant to uterine fibroids.
Objective: This study investigated the association between the use of CM and the incidence of uterine surgery in women with uterine fibroids.
Subjects and Methods: This retrospective cohort study extracted records for 16,690 subjects diagnosed with a uterine fibroid between 2000 and 2003 from the National Health Insurance reimbursement database. The risk factors for surgery were examined via Cox proportional hazard analysis, and the difference in incidence of surgery Between CM users and nonusers was compared using incidence rate ratios (IRRs) derived from Poisson's models.
Results: After an average follow-up period of 4.5 years, the cumulative incidence of uterine surgery was significantly lower in CM users than CM nonusers (P < 0.0001). Compared to CM nonusers, CM users were more unlikely to undergo uterine surgery (adjusted Hazard ratio = 0.18, 95% confidence interval (CI) = 0.17, 0.19). The incidence of surgery in CM users was different from that for CM nonusers (IRR = 0.17, 95% CI = 0.16, 0.18).
Conclusion: The risk of uterine surgery among fibroid patients who used CM was significantly decreased, implying an effective treatment of fibroid-related symptoms provided by CM.
Copyright © 2012 Shan-Yu Su et al. This is an open access article distributed under
The Creative Commons Attribution License
2. Material and Methods
1. Study Subjects.
2. Statistical Analysis
1. Characteristics of CM Users and CM Nonusers in Fibroid
2. Risk Factors for Uterine Surgery among Fibroid Patients
3. Incidence of Surgery among CM Users and CM Nonusers
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