Clinical Study: Sun Ten Medical Herb Complex Improve Immune Function on Cancer Patients


Effect of Citronellol and the Chinese Medical Herb Complex

on Cellular Immunity of Cancer Patients Receiving Chemotherapy/Radiotherapy


Shu-Ru Zhuang1,2, Su-Lin Chen1, Jih-Hsin Tsai3, Chi-Chou Huang2, Tzu-Chin Wu2, Wen-Shan Liu2, Hsien-Chun Tseng2, Hong-Sen Lee1, Min-Chang Huang4, Guang-Tzuu Shane4, Cheng-Hua Yang4, You-Cheng Shen1, Yeong-Yu Yan1 and Chin-Kun Wang1* 




Leukopenia and immunity impairment usually occur during cancer therapy. Citronellol, an oil soluble compound derived from the geranium, has anticancer and antiinflammatory properties, as well as promoting wound healing. Ganoderma lucidum, Codonopsis pilosula and Angelicae sinensis are traditional Chinese herbs, all of which have proven immunomodulatory functions in laboratory-based research. This randomized, doubleblind, placebo-controlled study examined whether the Chinese medicinal herb complex (CCMH; a mixture of citronellol and extracts of G. lucidum, C. pilosula and A. sinensis) improves the immune cell counts of cancer patients receiving chemotherapy and/or radiotherapy. A total of 105 cancer patients receiving chemotherapy or radiotherapy were enrolled. The quantities of immune cells in the blood of the subjects were determined before and after 6 weeks of cancer treatment, with either CCMH or a placebo. CCMH significantly reduced the depletion of leukocytes (14.2% compared with 28.2%) and neutrophils (11.0% compared with 29.1%). Analysis of the lymphocyte phenotype revealed that the patients receiving the placebo had reduced CD4 lymphocytes and natural killer (NK) cells than the CCMH-treated patients. Treatment with CCMH for patients receiving chemotherapy and/or radiotherapy may improve their immune function, improving their ability to fight off the cancer, as well as any secondary infections that could compromise their treatment and their health.


Keywords: citronellol; Ganoderma lucidum, Codonopsis pilosula, Angelicae sinensis immunity; cancer.

  1. Introduction
  2. Materials and Methods
    1. Participants
    2. Ingredients of CCMH: Four crude ingredients, G. lucidum extract (3 mg), C. pilosula extract (27.1 mg), A. sinensis extract (64.5 mg) and citronellol powder (273.6 mg) were mixed into a capsule (Table 1). All capsules were made by Sun Ten Pharmaceutical Co. Ltd, and provided by Medigreen Biotechnology Corporation.
    3. Biochemical analysis
    4. Statistical analysis
  3. Results and Discussion
    1. CCMH treatment affected hematological indicatory
    2. CCMH treatment reduces the loss of leukocytes and Neutrophils
    3. CCMH treatment reduces the loss of lymphocytes and NK cells, but not B cells
  4. References


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