TCM Principles - Modern Research in the Treatment of Dementia with TCM
TCM Principles
Modern Research in the Treatment of Dementia with TCM
By Dagmar Riley
Definition
According to DSM-IV, dementia is characterised by multiple cognitive deficits that are severe enough to cause significant impairment in social or occupational functioning. These deficits must show evidence of decline from previous levels of functioning, include memory impairment and at least one other cognitive disturbance (aphasia, apraxia, agnosia, or a disturbance in executive functioning). The rate of occurrence is higher in later life; the highest prevalence is above age 85. Dementia is classified as being progressive, static, or remitting. The subtypes of dementia are listed below:
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Dementia of the Alzheimer's type - deterioration of higher cortical function (the most common form).
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Vascular dementia - one form is multi-infarct dementia, which may be secondary to atherosclerosis.
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Dementia due to other general medical conditions, including infection with the human immunodeficiency virus (HIV), traumatic brain injury, Parkinson's disease, Huntington's disease, Pick's disease, Creutzfeldt-Jakob disease, normal-pressure hydrocephalus, hypothyroidism, brain tumor, and vitamin B deficiencies.
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Substance induced persisting dementia due to drug or alcohol abuse, medication, or toxin exposure.
Dementia and Chinese Medicine
In Traditional Chinese Medicine, there is no distinction between Alzheimer's Disease and Vascular Dementia. The symptoms of dementia fall under the category of lao nian xing chi dai and are often linked with kidney vacuity and marrow emptiness, spleen vacuity leading to internal phlegm-damp generation, ascendant liver yang, blood and/or phlegm stagnation, and toxicity.
The Kidney Engenders Marrow
The brain is nourished by the kidney, and insufficiency of the kidney may lead to emptiness of the sea of marrow, manifesting in brain deterioration. Hence, treatment with kidney tonics may slow down such a process.
Recommended herbs include Shu Di Huang [Cooked Rehmannia] to nourish kidney yin, Rou Cong Rong [Cistanche] to strengthen kidney yang; Wu Wei Zi to astringe kidney.
Recommended formulas include Liu Wei Di Huang Wan [Rehmannia Six Formula] or Ba Wei Di Huang Wan [Rehmannia Eight Formula]. The original contains Fu Zi [Aconite], which due to present Australian regulations cannot be used in a formula. This can be substituted with other yang supplementing herbs or inner warming herbs, such as Rou Gui [Cinnamon Bark]: Add Rou Gui [Cinnamon] to Liu Wei Di Huang Wan [Rehmannia Six Formula]. The heart stores the spirit. The heart is the seat of consciousness and mental function. Herbs that can be used in heart disharmonies disturbing mental function include Bai Zi Ren [Biota], Suan Zao Ren [Zizyphus], and Yuan Zhi [Polygala].
In addition to the above, special attention needs to be paid to blood stagnation and phlegm. Recommended formulas or singles include: Blood stasis: Dan Shen [Salvia], Chuan Xiong [Cnidium].
Phlegm: Digestives such as Liu Jun Zi Tang [Six Major Herbs Combination].
Blood Stasis and Ageing
In his article "Salvia and the History of Microcirculation Research in
Plant Name |
Active Ingredient |
Traditional Use |
AD Drug Target |
Ginsenoside Rg1
Ginsenoside |
TCM: Improve learning and memory function |
Secretase activity
Neprilysin |
|
Fresh plant extract |
TCM: for respiratory disorders, improve memory loss |
DemTec cognition score |
|
Akebia saponin D |
TCM: enhancing kidney function |
Aß toxicity |
|
1,2,3,4,6-penta-O-
galloyleta-d-
glucopyranose |
TCM: to treat inflammatory and pyretic disorders |
Aß fibril formation, stabilization; in vivo long-term |
|
Tenuifolin (extract) |
TCM: to improve memory loss |
Secretase activity: morphological plasticity |
|
Triterpenoids; Tanshinone |
TCM: to treat head conditions and stroke |
AChE activity; Aß toxicity in vivo and in vitro; NOS |
|
Extract |
TCM, TJM: enhancement of women’s health |
Apoptosis in vitro |
|
Monascus fermented red rice |
TCM: enhancement of blood flow |
Ach E activity, antioxidant; secretase activity |
|
Triterpene esters and uncarinic acids |
TCM: oriental medicine; improvement of cardiovascular and nervous system |
Aß aggregation and fibril stabilisation |
|
Ganoderic acid (Triterpen glycoside) |
TCM: as anti-tumor, immunomodulatory and immunotherapeutic agent |
Preserving synaptic density; preserving Aß-induced apoptosis |
|
Plysaccharides |
TCM: used as anti-tumor, immunomodulatory, anti-hypertension agent |
Reverses Aß and homocyteine induced apoptosis |
|
Composition of crude drug herbs |
TCM, Kampo: to treat restless leg syndrome and agitation in children |
Aß toxicity in vivo: decrease in anxiety, increase in locomotor activity in Tg2576 AD mice |
Summary of Research and Studies - Alzheimer’s Disease (AD)
Alzheimer's disease (AD) is the most common cause of dementia in the elderly, accounting for approximately 60% of cases of dementia. AD is defined as memory loss with at least one other area of cognitive impairment (e.g. language, attention, orientation, self-monitoring, judgment, motor skill, inability to perform daily activities).
Table One is an excerpt from the article, Traditional used plants against cognitive decline and Alzheimer disease, by Gunter Peter Eckert. The original table contains all traditionally used plants tested recently, however only the Chinese Medicine plants are summarised.
Most Frequently Used Herbs in TCM Classics
A study examined 27 ancient TCM books and established a database identifying 236 formulae for improving cognitive function, from which 10 TCM herbs were prioritised due to the highest frequency, The herbs were: Fu Ling [Hoelen], Ren Shen [Ginseng], Yuan Zhi [Polygala], Gan Cao [Licorice], Dang Gui [Angelica Sinensis], Shi Chang Pu [Acorus], Suan Zao Ren [Zizyphus], Shu Di Huang [Cooked Rehmannia], Mai Dong [Ophiopogon], Sheng Jiang [Fresh Ginger].
*Reproduced with kind permission from Health World Limited - Australia and New Ze