Extracts of bark from the traditional Chinese herb Phellodendron amurense inhibit contractility of the isolated rat prostate gland
Yuanhao Xu, Sabatino Ventura
Prostate Research Co-operative, Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia
Aim of the study:
To assess the effectiveness of the traditional Chinese herb Phellodendron amurense (Cortex Phellodendri; Huang Bo) in treating urological disorders.
Materials and methods:
Prostate smooth muscle relaxant activity of an extract from the bark of Phellodendron amurense (Cortex Phellodendri; Huang Bo) was tested on contractions of isolated rat prostate gland induced by electrical nerve stimulation and direct muscle stimulation.
Electrical field stimulation (0.5 ms, 60 V, 1–20 Hz) induced nerve mediated contractions of isolated rat prostate were inhibited by Phellodendron amurense (Cortex Phellodendri; Huang Bo) extract dissolved in either dimethylsulfoxide (DMSO), acetic acid or water (P≦0.022, n = 6 for each) but not boiling water (P = 0.619, n = 6). Phellodendron amurense (Cortex Phellodendri; Huang Bo) extract also inhibited contractions of isolated rat prostates elicited by exogenous administration of noradrenaline (10nM to 100μM), acetylcholine (10nM to 100μM) or adenosine 5-triphosphate (ATP, 100nM to 100μM) (P≦0.004, n = 6–8 for each).
Phellodendron amurense (Cortex Phellodendri; Huang Bo) is able to inhibit prostatic contractility suggesting that it may be useful in the treatment of urological disorders caused by prostatic urethral obstruction such as in the case of benign prostatic hyperplasia (BPH).
Keywords: Smooth muscle, Neuromuscular transmission,Benign prostatic hyperplasia(BPH)
Materials and methods
Isolated organ bath studies
Analysis of data
Effects of Phellodendron on contractile responses to nerve stimulation
Effects of Phellodendron on contractile responses to exogenously administered agonists
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